Tag: steroids

Categories
Doctor Q&A

Allergic Contact Dermatitis in Children (II) – Q&A with Dr Steve Xu

Allergic Contact Dermatitis in Children

This is a continuation of last week’s interview with Dr Steve Xu MD MSc where we discussed contact dermatitis, the differences between irritant and contact dermatitis, the top 10 pediatric contact allergens in personal hygiene products and practical consideration of when to suspect contact dermatitis in a child.

On ‘Bland’ Skincare Products Dermatologist Dr Steve Xu MD

MarcieMom: I’ve emphasized in my blog that the fewer the ingredients, the less likely it is to irritate (such as in this expert interview and also in the moisturizer selection post)

Practically it can be difficult to find a skincare product with less than 10 ingredients! Pharmaceutical companies seem to add more ingredients to their formulation in order to ‘upgrade’ their product to one that can restore your skin’s lipids, ceramides, reduce itch and bacterial infection.

MarcieMom: Is there a trend towards more ingredients in the formulation of skincare products? And is it a real risk or can consumers assume that product companies would have tested their increasingly complex formulation that it would not lead to contact dermatitis? 

Dr Steve Xu: Again, labels such as ‘hypo-allergenic’ or ‘sensitive skin’ really don’t mean anything. The Food and Drug Administration do not regulate this definition. Consumers have to be aware of this.

I wouldn’t say there’s a trend towards more ingredients in skincare products. Skincare products aren’t produced for hypo-allergenicity. These products are successful because they smell nice (fragrances), feel good on the skin, and stay fresh (preservatives). I think for individuals with patch-test proven allergic contact dermatitis, it’s really important to follow the safe list. But, if you haven’t been patch tested yet and have very sensitive skin, then looking for products with as few ingredients as possible AND do not have common skin allergens is a reasonable consideration.

Moisturizer Selection

Staph Bacteria and Antiseptic Moisturizer

MarcieMom: Staph bacteria has been covered in my blog, and we know that eczema skin that has staph bacteria colonization will not recover well due to inflammatory toxins from the bacteria. Are moisturizers for eczema/ dry skin incorporating antiseptic properties? Which antiseptics are now recommended for eczema children and how likely are these to irritate skin?

Dr Steve Xu: Absolutely, treating staph colonization is a big component of successfully treating atopic dermatitis. Moisturizers typically don’t have anti-bacterial ingredients. But, we do know that impaired or broken skin barrier facilitates the colonization and growth of staph. Thus, moisturizers play a big role in keeping the skin barrier intact so that staph can’t cause problems.

At least in the U.S., we hardly ever specifically recommend an ‘anti-septic’ moisturizer. It’s interesting to see that there are products out there marketed as such. We separate the use of moisturizers (barrier protection) and the elimination of colonizing bacteria (mupirocin ointment, bleach bathes). Typically for our patients, we always recommend moisturizers for skin barrier preservation but tend to be more reactive when it comes to recommending bleach bathes or mupirocin ointment at the sign of super infection (formation of pustules).

With that being said, lauric acid is certainly an ingredient that is becoming more and more popular. It is the key component in coconut oil, which has shown to have a broad range of antibacterial properties.

Long-story short, I think there’s probably a benefit from using antiseptics more regularly in managing atopic dermatitis. We know that the skin of eczema children have less anti-microbial peptides, natural bacteria fighting proteins produced by the skin. There’s no great head to head studies comparing coconut oil (moisturizer + anti-septic properties) vs. a regular moisturizer in managing atopic dermatitis. But, I think there is some benefit here that may be real for some patients that have a particular sensitivity to staph colonization.

Skin of eczema children is more susceptible to staph bacteria colonization
Skin of eczema children is more susceptible to staph bacteria colonization

Also, common over-the-counter topical antibiotics such as neomycin and bacitracin are notorious agents for causing allergic contact dermatitis. We typically do not recommend these for children with atopic dermatitis. In the United States, we prefer topical mupirocin (prescription only). This medication rarely causes allergic contact dermatitis compared to neomycin or bacitracin.

Age of Allergic Contact Dermatitis

In the article1, it was mentioned that studies have shown that there are different age (timing) where there is peak prevalence of contact allergy among children, being

  1. 0 – 3 years old – could be due to immature skin barrier, including lower lipid content, fewer natural moisturizing components, higher pH and thinner epidermis
  2. 6-7 years old
  3. Adolescence

MarcieMom: Are there a certain group of children who is more likely to have contact dermatitis? Narrowing this further, is there a particular profile of eczema children who are more likely to also have contact dermatitis?

Dr Steve Xu: This is a great question. I think certainly, older children and adolescents will have had greater exposure to potential allergens over time. However, an allergic contact dermatitis can occur at any age including toddlers. I think the most important thing is to have a high index of suspicion for allergic contact dermatitis in children with atopic dermatitis.

Is your child’s atopic dermatitis not getting better despite the best therapy?

Is your child’s atopic dermatitis appearing in areas that it never appeared before?

Are there eczematous rashes that seem to happen in the same locations such as the belly button, neck, waistband or wrist? Do the rashes appear linear (straight) or rectangular?

We’ve had plenty of pediatric patients with stable atopic dermatitis that would inexplicably get worse or not respond to therapy. After patch testing, we would identify a common allergen such as nickel. The rashes won’t get better unless nickel is avoided.

Corticosteroids

In the article1, it was mentioned that the most “allergenic” corticosteroids are:

  1. Budesonide
  2. Trixocortal pivalate
  3. Hydrocortisone butyrate

The least allergenic are those with halogenated C16-methylated molecules and in order of increasing potency:

  1. Aclomethasone dipropionate
  2. Beta-methasone valerate
  3. Memoetasone furoate
  4. Desoximethasone
  5. Clobatesol propionate
Corticosteroids - Potency and Allergenicity
Corticosteroids – Potency and Allergenicity

Again, there is the possibility of children with atopic dermatitis using more topical steroids and therefore getting hypersensitive to it overtime.

MarieMom: The article mentioned classifying topical steroid creams using different groups, based on their likelihood of being contact allergens. The likelihood can be due to different molecular (steroid) structure, the other non-steroid ingredients in the prescription cream, how long it is used and how occlusive it is (topical steroid creams are not recommended with wet wraps as absorption rates are higher than intended when occluded).

MarcieMom: What are the common steroid creams prescribed for young children with eczema? And how likely will they cause contact dermatitis?

Dr Steve Xu: Overall, a true allergic contact dermatitis to topical steroids is quite rare. Aclomethasone and desoximethasone are both popular choices.

I will say that sometimes it’s better judicious to not always reach for the least hypo-allergenic topical steroid at first. In the vast majority of time, a children will not have a contact allergy to a topical steroid. If we reach for a hypo-allergenic topical steroid and a contact allergy does develop, we have less therapeutic options in the future.

MarcieMom: Thank you Dr Steve for your time to help with this series; really glad for this interview as it has certainly raised my awareness of contact dermatitis in children (where previously thought to be remote).

References: 1. Hannah Hill, Alina Goldenberg, Linda Golkar, Kristyn Beck, Judith Williams & Sharon E. Jacob (2016): Pre-Emptive Avoidance Strategy (P.E.A.S.) – addressing allergic contact dermatitis in pediatric populations, Expert Review of Clinical Immunology, DOI: 10.1586/1744666X.2016.1142373

Brave Soldier Antiseptic Quick Healing Ointment with Tea Tree Oil,1 Ounce
Amazon.com
Brave Soldier Antiseptic Quick Healing Ointment with Tea Tree Oil,1 Ounce
$15.00
Buy
La Roche-Posay Effaclar Deep Cleansing Foaming Cream Cleanser, 4.2 Fl. Oz.
Amazon.com
La Roche-Posay Effaclar Deep Cleansing Foaming Cream Cleanser, 4.2 Fl. Oz.
$22.99
Buy
- 28%
100% Pure Organic Coconut MCT Facial Beauty Skin Oil By Alana Mitchell 2oz | All-Natural Pure Moisturizer Essential Oil for Body, Lips, Nails, Hair | Removes Makeup with Antioxidant Rich Ingredients
Amazon.com
100% Pure Organic Coconut MCT Facial Beauty Skin Oil By Alana Mitchell 2oz | All-Natural Pure Moisturizer Essential...
$25.00 $35.00 
Buy
Last updated on 20 November, 2024 2:51 pm
Categories
Doctor Q&A

Topical Corticosteroid Withdrawal – Q&A with Prof Hugo

In March 2015, the National Eczema Association (NEA, in US) published a study on steroid addiction in patients with atopic dermatitis. This was by members of its task force, who looked into the evidence regarding steroid withdrawal as many eczema sufferers were asking about the steroid addiction syndrome, along with many cautioning and enquiring on this online and over social media. The use of steroid creams remains a common treatment option, and the phobia of steroids has also stopped eczema sufferers, including children, from receiving treatment. The questions we are exploring with Professor Hugo centered on:

  1. What is steroid addiction?
  2. What is steroid withdrawal and its symptoms?
  3. Is steroid addiction/ withdrawal common?
  4. What are the treatment options for eczema?

Professor Hugo is no stranger to this blog – He has previously helped in Friday Doctor Q&A in 2012 and is my co-author for our book “Living with Eczema – Mom Asks, Doc Answers”. Professor Hugo van Bever is the Professor in Paediatrics (MD, PhD) at the National University Singapore, and also the Senior Consultant in its Division of Paediatric Allergy, Immunology & Rheumatology.

The questions are loosely structured based on the paper published by the National Eczema Association, to address the above questions that are surely on the minds of many parents with eczema children.

Topical corticosteroid withdrawal

What is Steroid Addiction?

MarcieMom: Steroid addiction is used broadly to refer to eczema sufferers whose skin are “addicted” to the topical corticosteroids, and therefore, when they stop applying the steroid creams, they experience steroid withdrawal and its adverse symptoms.

MarcieMom: I looked up the meaning of addiction online and found a broader definition by MedicineNet.com that defines addiction as

“An uncontrollable craving, seeking, and use of a substance such as alcohol or another drug. Dependence is such an issue with addiction that stopping is very difficult and causes severe physical and mental reactions.”

Medical definitions of addiction linked addiction to a brain disease, rather than a skin disease. Is it even possible for the skin to crave topical corticosteroids and be dependent on it to the extent that stopping is difficult?

Professor Hugo: I disagree with the word “addiction”, as the situation here doesn’t refer to a mental state (addiction always refers to a mental state). As for the possibility of the skin being addicted, the answer is NO!

To me, it is more a “bad habit” of using topical corticosteroids (TCS), mainly because of wrong expectations of this treatment. When used inappropriately (such as too long, too high, too frequent, or too strong), every medication (even a simple anti-fever medication) can cause side effects or unwanted (unexpected) effects. That’s why it doesn’t surprise me that inappropriate usage of TCS can cause withdrawal effects or, at least, unexpected side effects – I strongly doubt the existence of a withdrawal syndrome (especially when there are no specific biopsy features).

What is Steroid Withdrawal and its Symptoms?

MarcieMom: From Dermnetz, topical corticosteroid withdrawal refers to:

(1)   A rash that has appeared within days to weeks of discontinuing topical corticosteroid that has been used for many months. This flare may be worse than the pre-treatment rash. Before stopping the topical corticosteroid, the skin is typically normal or near-normal, although localised itch, ‘resistant’ patches of eczema or prurigo-like nodules may be present; and

(2)   The rash must be only where the topical corticosteroid was being applied, at least initially, although it can later spread more widely.

From the review article by NEA, there are two types of rash:

(1)   Eythematoedematous type – meaning redness (thus topical steroid withdrawal is also referred to as the Red Skin Syndrome), typically found in patients with an underlying eczema-like skin condition like atopic or seborrheic dermatitis; or

(2)   Papulopustular type – meaning with bumps and pimples, typically found in patients who used topical corticosteroids for cosmetic purpose like acne or pigment.

The withdrawal symptoms include:

  1. Burning and stinging
  2. Erythema (redness)
  3. Mostly on the face and genital area of women
  4. Exacerbation with heat or sun
  5. Pruritus (itch)
  6. Pain
  7. Facial hot flashes

Both types of rash primarily affect the face of adult females and are mostly associated with inappropriately using mid- to high-potency topical corticosteroids daily for more than 12 months.

MarcieMom: First of all, it is important to understand what a review article is. It is not a controlled trial, meaning there are no two groups of people that are given different treatments and thereafter the results are evaluated. Instead, it systematically reviews other studies. The limitation of the study is that the quality of evidence in regard to topical corticosteroid withdrawal in the studies reviewed were very low.

MarcieMom: Is there a way to study topical steroid withdrawal definitively?

Professor Hugo: The article is a collection of case reports, and not a study. There are no studies on the subject. Therefore, the quality of the science behind this is very low. It is a misuse of TCS, and you cannot ask patients (is not ethical) to misuse a treatment in order to prove side effects. Better is to look for its existence in patients who didn’t misuse TCS, but I assume the prevalence will be close to zero.

MarcieMom: It is also briefly discussed in the review article that the signs and symptoms of atopic dermatitis may be confused with that of steroid withdrawal. It is suggested in the review article that if:

(1) Burning is the prominent symptom, and

(2) Confluent erythema (meaning continuous red patches) occurs within days to weeks after stopping topical corticosteroids, with

(3) History of frequent, prolonged topical corticosteroid use on the face or genital region, then the symptoms are more likely to be from topical steroid withdrawal (rather than other forms of dermatitis).

MarcieMom: How do we know if the rash is caused by steroid withdrawal and not something else? Would you contact patch testing for contact allergens?

Professor Hugo: The so-called withdrawal syndrome (as a consequence of misusage of TCS) is mainly made-up by a re-occurrence of eczema lesions, as shown by looking at the results of the biopsy studies: the withdrawal syndrome has no specific biopsy features, but mainly features of eczema. Therefore, I am not sure whether the withdrawal syndrome is a separate entity, or whether it is mainly an expression of re-occurrence of eczema. Indeed, I strongly doubt of its existence.

I think the withdrawal syndrome is NOT a new syndrome, but merely a flare-up of eczema on an altered skin (because of the long-term usage of TCS).

It is not a new syndrome because:

  1. It has no specific clinical features (all manifestations might be manifestations of a re-occurring eczema)
  2. It has no biological marker (blood)
  3. It has no solid underlying mechanism – hypothesis
  4. Biopsy finding are similar of findings in eczema (no specific biopsy)

It is merely a re-manifestation eczema, but on an altered skin, because of the long-term usage (misusage) of TCS.

  1. Alterations of the skin can be summarized as following:
  2. A thinner epidermis (as a consequence of misuse of TCS)
  3. Higher Staphylococcus aureus colonization, as TCS do not affect Staph colonization – this explains the papular / pustular (infected) features of the lesions
  4. A concomitant contact dermatitis (to TCS or other substances)

Contact dermatitis is a possibility, but is not common in children (more in adults), especially after years of usage of creams.

Is Steroid Addiction/ Withdrawal common?

In the review article, there were various factors that contributed to topical corticosteroid withdrawal, namely:

  1. Mid or high potency use of topical corticosteroids
  2. Daily use of topical corticosteroids (only one out of the 34 studies recorded frequency)
  3. Duration of use longer than a year

From the studies reviewed, only 7.1% of the cases reported (in these studies) were of patients 18 years and younger. Only 0.3% were for children younger than 3 years.

MarcieMom: The general guideline in topical corticosteroid use for children is using a mild to (no higher than) mid potency, no more than twice a day, for a two week period. Professor Hugo, do you think that it is likely that children will suffer from topical steroid withdrawal even with the right use of prescribed steroid cream?

Professor Hugo: Patients should know that eczema (or atopic dermatitis) is a non-curable disease and that no doctor in the world can cure eczema today (perhaps in the future a cure will be found, mainly through immunomodulatory treatments, but not for the moment i.e. at the time of this interview in September 2016).

TCS are effective in controlling inflammation of the skin, and are, therefore, a part of the therapeutic approach to eczema. However: 1) TCS are ONLY (!) part of the treatment, which constitutes of offering a holistic package to the patient (focused on life style, and on usage of other treatments), and 2) once TSC are stopped the lesions will re-occur, as TCS do not cure, but only control inflammation, and 3) the rule is to use mild TCS (according to age and severity of the patches), in combination with antiseptics (TCS on a clean eczema patch) and NEVER more than 2 x day.

The main observation here is that this withdrawal effect is not caused by the TCS on itself, but by the inappropriate usage (i.e. misusage, leading to over-usage) of it. The unwanted effect was mainly seen in adult women (in more than 90%) who were using their TCS as if it was a kind of moisturizer. In other words, every time they felt a little itch or saw a little flare-up they put their TSC on it, many times per day, and during long periods (in 85.2% for more than 1 year).

The main point here is that TCS were misused, mainly because patients had wrong expectations of TCS, which I assumed is due to lack of correct information on eczema and on the role of TCS in its treatment. Who is to blame? I guess, both the doctor and the patient, and, for sure, the wrong doctor-patient relationship and wrong communication. Correct information on eczema and on the role of TCS is pivotal.

When TCS are used appropriately, as part of the holistic treatment of eczema, and according to correct expectations, it is extremely unlikely that a withdrawal syndrome will occur. I even dare to state that it is even (almost) impossible. However, I recommend close monitoring of all children with eczema, with appropriate individualization of treatment, focused on offering a treatment package in which TCS have a role, but only as a controller of acute inflammation, and with strict rules on their usage.

What are the treatment options for eczema?

MarcieMom: There are many brands and types of topical corticosteroid creams available, with varying potency and with different chemicals, and functions (for instance, with the added ingredients to reduce bacteria or fungus). Often, there is a trial and error process to see if a certain prescription cream works.

MarcieMom: How would a patient know if the steroid cream is not working for his rash? Is there a safe period of trial before stopping?

Professor Hugo: TCS are only PART of the treatment, and usually have a fast effect on acute inflammation (1 – 3 days). For each patient the optimal TCS needs to be selected (based on severity and age) and needs to fit into the whole package of treatment.

MarcieMom: There are many other eczema therapeutics that can be used alongside topical corticosteroids or in place of topical corticosteroids, for instance:

  1. Moisturizing – with a quality emollient that does not contain major irritants and have humectant properties and lipids to help with skin lipid deficiency
  2. Bathing – Basic good bathing routine like no hot water, no soap, no longer than ten minute, pat dry and not rub dry AND moisturizing immediately after
  3. Wet wrap or dry wrap
  4. Ways to reduce staph bacteria, such as swimming, using diluted zinc sulphate or chlorhexidine gluconate
  5. Non-steroidal prescriptions like topical calcineurin inhibitors
  6. Antihistamines (non-conclusive research)

MarcieMom: I’m a believer that one ought to diligently practice good bathing and moisturizing regime, reduce staph bacteria colonization, along with healthy lifestyle (non-inflammatory diet and exercise). However, I find that sometimes we tend to discuss topical corticosteroids exclusively, i.e. use topical corticosteroids or (do something else). What are your top 3 eczema therapeutics in your practice and how effective has these reduce the use of topical corticosteroids in your young patients?

Professor Hugo: My top 3 are: allergen avoidance (airborne food, house dust mites  – which is an outdoor life style) – usage of antiseptics (swimming – baby spa) and extensive usage of moisturizers have important additional effects and are therefore TCS-sparing.

MarcieMom: In summary, topical corticosteroid withdrawal is increasingly acknowledged by the dermatological community as evident by NEA taking the step to conduct a systematic review. However, we have seen that it is not easy to diagnose topical steroid withdrawal, and at the same time, removing topical corticosteroids completely as one of the eczema therapeutics may make it harder to treat the eczema/ skin inflammation. It is therefore important to recognize both the dangers of steroid misuse and underuse. Physicians should adopt an open attitude when hearing about patients’ steroid fears as totally ignoring steroid phobia would possibly alienate patients and without trust, it is making controlling eczema an uphill battle.

Hibiclens Antimicrobial/Antiseptic Skin Cleanser 16 Fluid Ounce Bottle with Foaming Pump for Antimicrobial Skin Cleansing
Amazon.com
Hibiclens Antimicrobial/Antiseptic Skin Cleanser 16 Fluid Ounce Bottle with Foaming Pump for Antimicrobial Skin...
$39.00
out of stock
Buy
- 24%
Tea Tree Body Wash Extra Strength Anti Fungal 10% - For Body Odor, Foot and Toenails - Helps Wash Away Dirt, Athletes Foot, Eczema, Ringworm, Jock itch, Acne 9 OZ By Buena Skin
Amazon.com
Tea Tree Body Wash Extra Strength Anti Fungal 10% - For Body Odor, Foot and Toenails - Helps Wash Away Dirt, Athletes...
$14.98 $19.95 
Buy
Housmile Anti-Dust Mites UV Vacuum Cleaner with Advanced HEPA Filtration and Double Powerful Suctions Eliminates Mites, Bed Bugs and Allergens for Mattresses, Pillows, Cloth Sofas, and Carpets
Amazon.com
Housmile Anti-Dust Mites UV Vacuum Cleaner with Advanced HEPA Filtration and Double Powerful Suctions Eliminates...
$96.99
Buy
Last updated on 20 November, 2024 3:13 pm
Categories
News & Research

Eczema News – High Blood Pressure Drug teamed with Corticosteroids

Hypertension drug with Steroid use reduces skin thinning

One of the key side effects of corticosteroid is skin thinning – this is also known as skin atrophy. Thinner skin has increased rate of transepidermal water loss (TEWL), more fragile and prone to irritation. The skin thinning is due to decreased rate of collagen and skin cell growth. The mechanism is from the activation of glucocoricoid and mineralocorticoid (MR) receptors in the epidermis by the corticosteroids.

Researchers in hypertension (high blood pressure) discovered that drugs for hypertension that contain spironolactone works as a MR antagonist by reducing the activation of the MR receptors. Based on a small randomized double-blind controlled trial of 23 individuals for 28 days, it was recorded that there was no skin thinning for those who applied spironolactone. Thus, it was an indication that corticosteroids could possibly be used without the worry of skin thinning effect if it’s applied together with the above hypertension drug. 

It is interesting to see if there’s medical advancement in this area – steroid side-effect is a concern of many parents and while generally safe to use, always bear in mind to use as indicated and check with your doctor

  • How much to use (finger tip unit)
  • How long to use (duration and frequency)
  • Where it can be used (especially for thinner areas of skin such as face and neck)
  • What appearance of rash you should see after application by week (1,2 and when to stop)
  • How it can be used – especially if you are also applying wet or dry wrap, you should not also be using corticosteroids as under occlusion, the side effects are more significant
- 10%
Neosporin Eczema Essentials Daily Moisturizing Cream, 6 Oz
Amazon.com
Neosporin Eczema Essentials Daily Moisturizing Cream, 6 Oz
$10.99 $12.31 
Buy
- 6%
Aveeno Eczema Therapy Daily Moisturizing Cream for Sensitive Skin, Soothing Lotion with Colloidal Oatmeal for Dry, Itchy, and Irritated Skin, Steroid-Free and Fragrance-Free, 7.3 oz
Amazon.com
Aveeno Eczema Therapy Daily Moisturizing Cream for Sensitive Skin, Soothing Lotion with Colloidal Oatmeal for Dry,...
$10.88 $11.69 
Buy
- 8%
Curél Hydra Silk Itch Defense Moisturizer, 12 Ounce Dry, Itchy Skin Therapy Lotion, with Oatmeal Extract, and Vitamin E, Experience Non-irritating Hydration
Amazon.com
Curél Hydra Silk Itch Defense Moisturizer, 12 Ounce Dry, Itchy Skin Therapy Lotion, with Oatmeal Extract, and Vitamin...
$10.94 $11.99 
Buy
Last updated on 17 November, 2024 8:50 pm
Categories
Doctor Q&A

Rise and Shine Feature – Eczema Skin Function and Care

Dr Lynn Chiam Dermatologist Children Skin Conditions Eczema

Dr Lynn Chiam shared during the Rise and Shine Expo on ‘All about Children’s Skin’. She consults at Children & Adult Skin Hair Laser Clinic and subspecializes in pediatric skin conditions. She was formerly the head of pediatric dermatology at National Skin Centre, Singapore. She has also shared her expertise on Teen Eczema, Hand Eczema and Facial Eczema.

Eczema Baby Skin

MarcieMom: Thanks Dr Lynn for spending some time here, and helping to address follow-up questions to your talk. You mentioned that the skin function includes protection against sun, and that baby’s skin offers less protection. How about skin of an eczema infant? And the skin of an eczema adult? Do they offer even less protection against the sun as the skin barrier of eczema patients are already defective?

Dr Lynn: Protection against the sun depends on the integrity of the skin as well as the amount of pigment cells in the skin. In general, a baby’s skin is less mature and contains less pigment cells compared to an adult and thus is more susceptible to the adverse effects of the sun. Darker- skinned individual tend to get less sun burn as compared to fair-skinned individuals.

In infants and adults with eczema, their skin barrier functions is defective and they can get broken skin as a result of scratching. This can make them more susceptible to sunlight and exposure to excessive amount of sunlight is known to trigger or aggravate the eczema.

Eczema Baby Skin is more susceptible to sunlight and exposure to excessive amount of sunlight is known to trigger or aggravate the eczema.

Eczema Baby Skin Infections

MarcieMom: You also mentioned that the skin forms part of our body’s immune system. Is this due to the skin flora? Does the ‘porous’ eczema skin means that babies with eczema have a lower immunity and does this lower immunity translate to falling sick often? What is the implication for parents in caring for the general health of an eczema baby?

Dr Lynn: The skin contains cells which are involved in the reaction that our body mounts in response to an infection and inflammation. They are known as “B” cells and “T” cells. They can be thought of as “soldier cells” that defend our body when it is “attacked”. The skin flora on the other hand describes the bacteria, fungi and viruses that reside on our skin without causing any harm to our body. They are not part of the immune system.

The “porous” eczema skin allows bacteria and viruses to penetrate more easily and thus eczema patients are at a higher risk of getting skin infections. The skin of patients with eczema do have lower immunity to prevent skin infections but in general this not lead to overall decrease in their body’s  immunity. Children with eczema  do not fall sick more often as compared to their peers.

It is important for parents and health care providers to recognise eczema superimposed with skin infection as the skin infection has to be cleared for the eczema to heal well.

Wet Wrapping for Eczema Baby

MarcieMom: Is wet wrap/dressing recommended for infants below 6 month old? Does the thinner skin of babies affect whether they ought to be wet wrapped?

Dr Lynn: As the skin of an infant below 6 months has a larger surface area: volume and is thinner as compared to adults, they tend to absorb a larger percentage of creams that is applied. Thus it may lead to side effects as a consequence of more creams that is absorbed via the skin into their system. Thus I will generally not advise wet wraps for infants unless the eczema is very severe and the creams used are very gentle.

Wet wrap is not advisable for infants unless the eczema is very severe and the creams used are very gentle

Topical Steroid Potency for Baby

MarcieMom: Similarly for steroid potency, is there a certain age by which the skin is thick enough to consider stronger potency steroid cream?

Dr Lynn: There are no guidelines for the potencies of steroids to be used according to age. In general, I will not use anything stronger than a mid-potency steroid in children less than 8 years old. The potency of the steroid used also depends on the thickness of the skin and the severity of the eczema. The neck, inner aspects of elbows, back of knees and wrist are generally considered to have thin skin and only low to mid-potency steroids should be used. Contrary to this, more potent steroids have to be used on the palms, soles and areas where the skin is thick as a result of the eczema.

For more severe eczema, a more potent steroid should be used to control the inflammation before tailing to a less potent one.

Thank you Dr Lynn for sharing your thoughts on the above questions, and thank you for the wealth of information you’ve provided in this blog.

Tubifast 4.3 Tubular Bandage #2440 (Yellow Line)""
Amazon.com
Tubifast 4.3 Tubular Bandage #2440 (Yellow Line)""
$26.99
Buy
TUBIFAST VESTS FULL SLEEVE 2-5 YEARS (NEW) 2-WAY STREATCH TECHNOLOGY GARMENT - 2-5 YRS by TUBIFAST
Amazon.com
TUBIFAST VESTS FULL SLEEVE 2-5 YEARS (NEW) 2-WAY STREATCH TECHNOLOGY GARMENT - 2-5 YRS by TUBIFAST
$88.95
out of stock
Buy
SCHULKE OCTENISAN ANTIMICROBIAL WASH LOTION - 500ML by Octenisan
Amazon.com
SCHULKE OCTENISAN ANTIMICROBIAL WASH LOTION - 500ML by Octenisan
out of stock
Buy
Categories
Living with Eczema

SOMEONE Manages Baby with Severe Eczema

Someone has eczema severe baby eczema Lauren Story on EczemaBlues

Lauren Son Eczema Blues
Lauren shares about managing severe eczema for her son in his first year

This is a series focused on personal journey with eczema while managing a certain aspect of life. Today, we have Lauren, whose 3 year old son has severe eczema in his first year, and shares how she manages eczema for a newborn. Lauren plays and teaches bassoon in Traverse City, Michigan.

Marcie Mom: Hi Lauren, it’s good to have you share in this series! Let’s start with you sharing a little of your son’s eczema – when did it start and how was his skin at his worst then?

Lauren: Hi, Mei. Rhys developed cradle cap (a yellow, scaly crust on his scalp) around two months of age and developed body-wide severe eczema at three months of age.  I first noticed a problem when one day he started to repeatedly rub his eyes and face with his hands.  He was not yet coordinated enough to truly scratch.  The red skin and rashes followed, at first on his face, and later nearly everywhere else.  At its worst, his skin was inflamed, crusty, and oozing and the plasma would soak through his clothes and bed sheets.  It was quite similar to a very bad reaction to poison ivy.

Marcie Mom: Allergy testing isn’t accurate in the first few months of a newborn’s life  – did you have difficulty finding out his triggers in the first year?

Lauren: My husband and I had tremendous difficulty and often had disagreements stemming from the mystery of it all.  That first year we took Rhys to three different doctors and also to non-traditional (in the American sense) healers.  I stopped consuming dairy for about a month because I was breastfeeding, we eliminated all detergents from our home – even shampoos and toothpastes containing detergents, and we kept Rhys away from our cats.  No lifestyle change seemed to make an obvious improvement.

Marcie Mom: How and when did the eczema improve?

Lauren: During the first year, it was a combination of two events.  First, Rhys’s pediatrician realized he couldn’t fully help and referred us to a dermatologist.  The dermatologist prescribed Triamcinolone, a strong topical steroid, and frequent moisturizing.  I believe he gave us samples of CeraVe. Second, around the same time, I spoke with a friend whose son has food allergies.  She told me dairy consumption was often a trigger for eczema breakouts and other allergic reactions and convinced me to again eliminate dairy from my diet.  She also told me about a friend of hers whose child had severe eczema.  The pediatric dermatologist in that case had advised to (1) give the child three lukewarm baths a day, using cleanser only on soiled areas, (2) use topical steroid as needed on “hot spots” after the bath, and (3) moisturize on still-damp skin.  The triamcinolone broke the cycle of inflammation and the frequent bathing and moisturizing helped his skin’s resiliency.  Moisturizing red and oozing skin never worked; it was really only effective at maintaining healthy skin.

As you mentioned, Rhys is now three.  We no longer give him baths three times a day, but we do moisturize after baths and as needed throughout the day and we use the steroid Fluticasone Propionate Cream for break-outs.  We still avoid detergents and products with synthetic scents.  Rhys underwent allergy testing late last summer and due to the results and personal experience, we now avoid peanuts, tree nuts, legumes, dairy, and eggs.  If Rhys begins to scratch uncontrollably, the dermatologist gave us permission to give him children’s strength antihistamine.  We have so many more pieces of the puzzle figured out now, not all, but many.  Most of Rhys’s skin is now smooth and healthy.

Marcie Mom: One final question – what advice would you give to a mom who has a family history of eczema/allergy and preparing for the newborn?

Lauren: Eat the healthiest possible foods while pregnant.  Some might even advise you to eat as much chemical-free and organic food as possible while pregnant.  If your baby develops the symptoms I mentioned, do your best to keep the baby from scratching and seek help.  If your child’s healthcare provider has never seen such a severe case of eczema, find a healthcare provider who has already seen and treated a case like your child’s before.  And don’t blame yourself.  Your baby will outgrow some triggers, like the drooling that accompanies teething.

Marcie Mom: Thank you Lauren for your sharing, many moms can identify with it and hopefully every baby grows out of eczema.

Puracy Natural Liquid Laundry Detergent (192 Loads), Hypoallergenic, Enzyme-Based, Fresh Linen, 24 Ounce (Pack of 2)
Amazon.com
Puracy Natural Liquid Laundry Detergent (192 Loads), Hypoallergenic, Enzyme-Based, Fresh Linen, 24 Ounce (Pack of 2)
out of stock
Buy
CeraVe Moisturizing Cream for Itch Relief | 12 Ounce | Dry Skin Itch Relief Cream with Pramoxine Hydrochloride | Fragrance Free
Amazon.com
CeraVe Moisturizing Cream for Itch Relief | 12 Ounce | Dry Skin Itch Relief Cream with Pramoxine Hydrochloride |...
$19.97 $19.99 
Buy
- 1%
CeraVe Foaming Facial Cleanser | 16 Ounce | Daily Face Wash for Oily Skin | Fragrance Free
Amazon.com
CeraVe Foaming Facial Cleanser | 16 Ounce | Daily Face Wash for Oily Skin | Fragrance Free
$13.79 $13.99 
Buy
Last updated on 15 November, 2024 10:52 am
Categories
Eczema Facts

Eczema Medication Series – Prednisolone

Marcie says 'Prednisolone worked for me!' MarcieMom says THANK YOU GOD
Marcie says ‘Prednisolone worked for me!’ MarcieMom says THANK YOU GOD

This is a series on some of the medication that I’ve collated from parents who shared in forums. For this week on Prednisolone, my baby with eczema had been prescribed a one-time 3 week reducing dosage course at about 7 month old, and it had cleared her eczema which then became manageable after the course. I know of many other young children, who did not respond well after the course, and some who did – please freely share your experience in the comments, your sharing can help encourage and comfort another parent.

What is Prednisolone?

Prednisolone is a type of corticosteroid which is prescribed to control inflammatory and allergic conditions like eczema, severe psoriasis and severe seborrheic dermatitis, colitis, asthma and rheumatoid arthritis. It works by stopping the release of chemicals that cause inflammation. Prednisolone is also used to treat blood cancer and lymphoma, to reduce the destruction of platelets by the body’s immune system.

It is usually an oral prescription (for my girl, it was solution) that must be complied strictly. Self-altering the dosage is not acceptable as the dosage is decided by a skilled physician, taking into account a combination of factors such as the skin condition and weight. If you are in a highly stressed season in life, do let your doctor know as that is a factor for deciding on the dosage.

From personal experience, the skin of the baby changes during the course – it may get better than worse, for my child, better again. Terminating halfway on your own, due to fear of oral steroid or deterioration of eczema, will make it more difficult for the doctor to make an assessment of how the course worked (or not).

Monitoring

Monitor your child’s growth and if concerned, discuss with the doctor. Steroid course may slow a child’s growth if used over long period or cause thinning of bones (osteoporosis), as it impairs calcium absorption and new bone formation. Look out also for signs of vision changes.

Warning

There are interactions with other medications so it’s best to let your doctor know of medication, vitamins and supplements that you or your baby/child is taking. Taking steroid over a long period can lower the body’s immunity. Avoid contact with people who are ill (esp. with chicken pox, measles or shingles), and also those who have taken a recent live vaccine (also check with the doctor before your child gets vaccinated). Wash hands also to prevent infection.

Side Effects

Watch for side effects, one of which is adrenal issue whose symptoms are fainting, irregular heartbeat, thirst, irritability or unusual fatigue. Click here for a list of common to less seen symptoms.

There is no particular diet to follow (except avoid liquorice), unless directed by your doctor.

Most Importantly, Does it Work?

I’ve found a study of 21 patients, only 1 achieved stable remission of eczema versus a higher rate (6 out of 17) for those prescribed cyclosporine. I find it strange though that I couldn’t find more study on Pubmed for prednisolone than for other medications in this series, which are licensed for use later. I’m glad that oral steroid course worked for my child, and love to know how it worked out for you.

For previous posts in this series, see

Cyclosporine

Methotrexate

Cellcept

Categories
Doctor Q&A Support Group

Sharing Treatment for Eczema Children

Eczema Treatment for Children Dr Lynn Chiam dermatologist Singapore
Elomet ointment

Last Friday’s eczema support group session with Dr Lynn Chiam was a fruitful one – the topic was Treatment for Kids’ Eczema and we had pizza and chicken wings for lunch at the National Skin Centre Singapore!
Dr Lynn is a consultant dermatologist who subspecializes in paediatric skin conditions at Mount Elizabeth Novena Specialist Medical Centre, Children & Adult Skin Hair Laser Clinic, Singapore.

Eczema Tips for Children

1. Moisturizing within 3 Minutes After Shower

This is inline with Dr Jennifer Shu’s tip here, so it appears that it’s an international recommended practice. Dr Lynn shared that should it be difficult to do so, or if skin is still dry, wet wrap can be implemented. For practical purpose, should the child not be able to tolerate wet wrap overnight, instead implement at least an hour, 5 times a week. Even a dry wrap will retain moisturizer better for the skin.

2. Removing House Dust Mite (if it is an allergen for your child)

Dust mite can be killed either by extreme cold or heat – so wash bedsheet in at least 60 deg C water (read this post) and for stuff toys, freezing them may help decrease the amount of dust mite as they are affected by extremes of temperature. Dr Lynn recommended sunning mattresses and changing mattress once per year, i.e. don’t get a thick and very expensive one. Remove carpets.

3. Use of Topical Steroid – Don’t be Steroid-Phobia

I shared that there is a lot of fear out there among parents on using even the mildest steroid cream, and I’ve heard of increasing number of children hospitalized for infections due to fear of using steroid. Read more here on ‘Is Steroid Cream Safe?’. Dr Lynn explained 4 side effects of topical steroid (i) skin thinning (ii) easy bruising, (iii) fragile blood vessels and (iv) excessive hair growth. However, these can be avoided if patients ensure they use (1) the right steroid (2) at the right part of skin and (3) for the right amount of time. 

Topical Corticosteroid Withdrawal Children

Read this interview with Professor Hugo where we go through the review paper conducted by National Eczema Association on Topical Corticosteroid Withdrawal

For anyone who emailed me (and we’re talking many!) who ask if steroid cream is safe because they’ve read about the side effects (which further reinforces FEAR spread like FIRE), you know my reply is the side effects of MISUSE should not be confused with Right Use. There are also many who have an agenda for propagating fear – to sell a steroid-alternative. Again, there is no need to use one and not the other. You can use steroid safely to treat flare-ups and skin inflammation, while at the same time, moisturize, wet wrap, have healthy diet, healthy lifestyle, distract your child, protect their skin, covering their fingers..


Side effects of MISUSE should not be confused with Right Use

Dr Lynn shared that steroid treatment should be used pro-actively, to treat skin inflammation even after the rash disappear, and this is also consistent with what Dr Bridgett shared in this post. Protopic can be used for maintenance, and I’ve clarified with Dr Lynn that the stinging sensation that some experienced with Protopic will not be manifest as rashes. For more on Protopic, see here.

4. On Oral Steroid

This is usually a treatment for severe active cases, not lightly prescribed due to its side effects of osteoporosis, stunting growth and increased vulnerability to infection. Tomorrow’s post is on prednisolone, and you can also refer to previous post on cyclosporine.

5. This is my afterthought – Don’t Jump from Fear to Fire

I’ve shared earlier that Fears spreads like Fire, and I like to remind parents not to jump from fear into fire – for instance:

Is someone telling you not to use steroid but something natural? If so, do ask them and search Pubmed for studies. I’m not against natural and I’m not against any parent wanting to try something natural. Do check 1. It’s safe to consume/apply, 2. Keep up the standard treatment.

Is someone telling you that a steroid cream is not working and that the flare is caused by it? Think back – did your child have rashes before the steroid? and Dr Lynn shared that each steroid cream has its own molecular structure, suited for different purpose. You may wish to work with your doctor on another cream.

Is someone telling you their skin recovers after doing a,b,c and d? Ask them, did they do a,b,c and d while applying the steroid?

Is your doctor (I really hope not) telling you that established clinically trialed cream is no good and their own concoction is better? I do not know if it is/not, how would anyone know if it’s kept a secret, even without a medical name. If it doesn’t work for your child, it’d be impossible for the next doctor to understand what your child has been prescribed and how the skin reacted.

This is a very long summary of the discussion. But as you can see, I’m really AGAINST people who spread fear of steroid – again, I’m not saying steroid is the only way, I’m saying it has its place and fear shouldn’t be propagated for personal means.

Tubifast 4.3 Tubular Bandage #2440 (Yellow Line)""
Amazon.com
Tubifast 4.3 Tubular Bandage #2440 (Yellow Line)""
$23.17
Buy
Physiogel Calming Relief AI Cream 100ml
Amazon.com
Physiogel Calming Relief AI Cream 100ml
$66.50
Buy
Housmile Anti-Dust Mites UV Vacuum Cleaner with Advanced HEPA Filtration and Double Powerful Suctions Eliminates Mites, Bed Bugs and Allergens for Mattresses, Pillows, Cloth Sofas, and Carpets
Amazon.com
Housmile Anti-Dust Mites UV Vacuum Cleaner with Advanced HEPA Filtration and Double Powerful Suctions Eliminates...
out of stock
Buy
Categories
Eczema Facts

Protopic – Is a Non-Steroid Cream Better for your Child?

Picture from protopic-la.com

This is a post that I wanted to write for some time because I’ve been reading parents’ differing views on whether Protopic has worked for their child. I did a quick internet search on forums, and 10 out of 14 parents said it worked, 3 mentioned it gave a stinging sensation and 1 believed it led to herpes virus. Of course, my limited browsing of forum posts is not a scientific study but it certainly has piqued my interest to find out more about Protopic (something I didn’t research earlier because a mom with eczema child is busy! and also Marcie doesn’t use nor has been prescribed Protopic).

So What’s Protopic and what does it do?

According to its website, Protopic is a topical calcineurin inhibitor (TCI) that is available upon prescription. Calcineurin activates the T-cells of the immune system, which when over-produced attacks the skin leading to inflammation (read more in this post). Protopic, whose drug name is tacrolimus, belongs to a class of drugs known as calcineurin inhibitors and works to decrease the effects of, or suppresses, the immune system. Tacrolimus is also known as FK-506 or fujimycin and typically prescribed to reduce the likelihood of new organs being rejected in a transplant operation. Tacrolimus was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Protopic is a product of Japanese pharmaceutical company, Astellas Pharma, and its ingredients are tacrolimus, mineral oil, paraffin, propylene carbonate, white petrolatum and white wax.

Who can and How to use Protopic?

It is recommended for moderate to severe eczema and to be prescribed by doctors, who are to prescribe it only when topical corticosteroids are not effective. It is only to be used for short periods, generally not more than 6 weeks. It comes in two strengths, 0.1% and 0.03% but for children (at least 2 years of age), only the 0.03% is recommended. The application of Protopic ought to be thin and improvement (if any) is usually seen in two weeks.

Protopic is not to be used with wet wraps, lest there’s over-absorption into the body. Protopic should also not be used on eczema that is infected as there’s no study relating to its safety in infected eczema. Going outdoors in the sun and tanning beds are also to be avoided because of shorter time to tumor formation when applying Protopic, as disclosed on their website. Hands ought to be washed after applying Protopic. The long-term use of Protopic has not been studied and thus, its application as a maintenance topical treatment to prevent flare-ups need to be advised by doctors. It is also not recommended for nursing moms or moms who are trying to be pregnant.

Pros and Cons of Protopic

Various studies have been conducted on Protopic, and it appears to be more effective than low-potency steroid creams. The other advantages over steroid creams is that it doesn’t cause skin thinning and therefore can be used on parts of other where skin is generally thinner, such as the face, eyelids and neck. However, as it suppresses the immune system, there’s increased risk of viral infection, in particular from herpes/ eczema herpeticum/ chickenpox/ shingles virus. Skin burning and itching sensations are the most common side effects (usually in its initial use) of using Protopic. It is also possible to be allergic to tacrolimus or other ingredients in Protopic, such as mineral oil and paraffin. Furthermore, a number of cases of cancer of skin or of lymphocytes cells have been reported, resulting in FDA issuing a black box cancer warning (read more on webmd post). Protopic may also interact with certain medications, including some antibiotics such as azithromycin which is commonly prescribed to children. You can read the product leaflet here.

Update in Feb 2015 – 10 year follow-up study on children who use pimecrolimus showed no significant cancer risk.

MarcieMom’s Take?

Marcie hasn’t been prescribed Protopic but from various talks that I’ve attended, it appears that though calcineurin inhibitors are mentioned, it’s always fairly down in the list of treatment options. One thing I feel is clear is that I wouldn’t opt to use Protopic just because I’m worried about the side effects of steroids as a drug that works on the immune system would surely has its own sets of side effects.

Categories
Doctor Q&A Other treatments

Combined Approach Series – Topical Treatment

Dr. Christopher Bridgett is Hon. Clinical Senior Lecturer Imperial College at Chelsea & Westminster Hospital London. He is a psychiatrist with a special interest of using behavioural interventions to help people with atopic eczema, co-author of The Combined Approach at AtopicSkinDisease.com

Habitual Scratching and Eczema with Dr Christopher Bridgett

Explaining Topical Treatment – Moisturizer

The Combined Approach includes topical treatment using emollient and steroid. Moisturizing is a HUGE part of topical treatment, as emollients both lubricate and moisturize. Dr Bridgett’s advice on moisturizing is Thinly, Gently, Quickly and Often. There are a few other points mentioned in the ‘Atopic Skin Disease’:

  1. Thinnest possible application without ‘rubbing it in’
  2. More on exposed areas such as the head, neck and hands
  3. Pump dispensers preferable to open tubs due to bacteria infection
  4. Applying topical steroid first, then emollient over both the skin and the steroid
  5. Cream preferred over lotion

Can you explain why thinnest possible application is preferable for emollient?

(I’d usually slather on my child as I find applying a thin layer leads to more rubbing to spread the emollient)

Also, can you explain why topical steroid first?

(I’d written on this here and it does generate some discussion!)

Can you explain why cream is preferable over lotion?

Dr Bridgett: Your three questions answered:

  • Thin applications of moisturizer allows heat to escape, but insulates against water loss.
  • If moisturizer is applied often enough, when the steroid is applied directly onto the eczema, it is applied to skin that has been recently moisturized. We get then the best results by putting moisturizer on over topical steroid, and moisturizing all the skin, not just that which has the eczema.
  • The thicker the moisturizer, the better the moisturizing effect. Also, often there are less additives in thicker moisturizers, as thicker moisturizers “keep” longer. There is less chance that a sensitivity reaction will occur with an ointment, compared with a cream. See http://atopicskindisease.com/articles/20110801

Explaining Topical Treatment – Steroid

It is stated in ‘Atopic Skin Disease’ manual that steroid cream work by inhibiting protein synthesis, secretion of products, cell division and migration of cells. The epidermis can benefit from reduced cell division, and the dermis from reduced cellular and lymphokine activity. Can you explain what this means, and

why it is important to continue steroid treatment after epidermis healing (‘2-stage in steroid effect’)?

Dr Bridgett: It seems the steroid anti-inflammatory effect is partly achieved by reducing over-activity in the skin, allowing natural healing then to lay down healthy skin again. By the time the seems good to look at, the healing is not complete through and through – there is more that is needed under the surface, so we recommend continuing with the topical steroid, beyond The Look Good Point: do not stop too soon. See http://atopicskindisease.com/articles/TT7

Many parents are very concerned with the skin-thinning side effects of steroid and also the ‘withdrawal’ symptoms once steroid treatment is discontinued. I read in your manual that side-effects are associated with inappropriate use of topical steroid and the risk is usually inadequate treatment (i.e. stopping steroid cream too early or using one of too low strength).

How do you normally convince parents that steroid cream is safe? And what guidelines would you give them to gauge if the steroid cream of correct potency, frequency and amount is used?

Dr Bridgett: Steroid side-effects come especially from using topical steroids long-term and in an unsupervised way. The method we use in The Combined Approach includes more supervision than is usually given, with a programme of several clinic visits, involving careful discussion of all anxieties and concerns. Using The Combined Approach, including therefore habit reversal, which allows natural healing alongside the good steroid effect. Then less topical steroid is used overall, for good effects, not side effects!

We offer information about the potency groups of the topical steroids, and how they are usually used. The thicker the skin, the stronger the topical steroid to be used. See http://atopicskindisease.com/categories/20110423_11

Each application of any cream needs to be sparingly applied – whether it is an emollient or a topical steroid: only a shine is required.

MarcieMom: Thank you Dr Christopher Bridgett for explaining the topical treatment that is part of The Combined Approach. In our next post, we will understand more on habit reversal techniques.

Bioderma Atoderm Intensive Balm For Very Dry to Atopic Sensitive Skin
Amazon.com
Bioderma Atoderm Intensive Balm For Very Dry to Atopic Sensitive Skin
$24.90
Buy
Dash Sensations 4335515815 Water Motion Liquid Bubble Timer – Calming Sensory Fidget and Relaxation Desk Toy - Therapeutic Focus Game for Kids with ADHD, Autism and More - Blue, 1 Pink
Amazon.com
Dash Sensations 4335515815 Water Motion Liquid Bubble Timer – Calming Sensory Fidget and Relaxation Desk Toy -...
$7.99
Buy
Physiogel Calming Relief AI Cream 100ml
Amazon.com
Physiogel Calming Relief AI Cream 100ml
out of stock
Buy
Categories
Doctor Q&A

Friday Dr Q&A with Prof Hugo – Skin Prick Test

Q&A Senior Consultant Allergy Immunology Professor Hugo for EczemaBlues

Professor Hugo van Bever is a Senior Consultant in Pediatric Allergy and Immunology at the National University Hospital, Singapore. He is an active member of the board Asia Pacific Academy of Pediatric Allergy, Respirology and Immunology. He is also my co-author for Living with Eczema: Mom Asks, Doc Answers!

This is originally a series of Friday Q&As in 2012 which has been combined into one informative post.

Eczema Baby Scratching Eyes

MarcieMom: Babies tend to scratch their eyes when tired. Also, I notice that my baby’s eyelids (where eyeliner is applied) look oily. To soothe the discomfort, I would wet a cotton pad with lukewarm boiled water and clean outwards. This is sometimes followed by moisturizing sparingly when her eyelid is dry.

How would you recommend a parent to reduce their child scratching eyes?

Prof Hugo: Keep eczema under control and apply a preventive approach.

Skin Prick Test for Kids

Marcie Mom: Today’s questions is on skin prick test, something I always recommend parents to do (in this post).
In a skin prick test, typically a few common food allergens such as egg and milk will be tested instead of all possible food that the child may eat. Why is testing a few of these food allergens sufficient to diagnose if there’s an underlying food allergy?

How often should a child get retested for food allergy? And what type of patients needs to be retested regularly?

Anti-histamines should be avoided before a skin prick test so as to avoid incorrect results (due to no reaction seen when there should be one). What else should a parent take note before bringing the child for allergy test?

Prof Hugo: Because only a few foods are involved in eczema, mainly in young children. These are: cow’s milk, egg, wheat and soy. Other foods are very seldom involved in eczema. In older children food allergy is usually not involved in eczema. Older children have mainly an allergy to house dust mites.

If the child improves there is no need to repeat skin prick test.

Skin prick test should be performed only when the child is in good health (no ongoing infection, no fever) and did not take antihistamines for at least 3 days. Antihistamines may suppress the skin prick test’s results, leading to false negative results. Skin prick test also needs an area of normal skin. In cases of severe eczema, skin prick test’s results are difficult to interpret. A blood test might be an alternative.

Topical Steroid as Treatment

MarcieMom: Many parents are worried about applying steroid cream for their child’s eczema. Recent research has shown that there is no major negative effect on the skin of children who have applied topical steroid over approximately 10 months, including no evidence of skin thinning.

What guidelines will you provide parents when applying steroids for their child (in terms of when to apply, how much to apply and which part of the skin to apply which steroid’s strength)?

Prof Hugo: Use mild steroids (for children) maximum 2 x day. Use them only on active inflammation (= “red” patches) and use them after cleaning the patches. Don’t use steroids on a dry skin or on old lesions.

Topical Corticosteroid Withdrawal – Q&A with Prof Hugo

Oral Steroid as Eczema Treatment

Marcie Mom: I must thank you again for helping Marcie with her eczema. I noticed that it got much better after the one-time oral steroid course you prescribed (read more in this post).

Oral steroid such as prednisolone is sometimes prescribed for children with severe eczema. Can a child only be prescribed oral steroid once? I’ve read horror stories online of how some doctors negligently keep prescribing oral steroid to the point that it no longer works for the child. How can a parent assess if the doctor is taking due care in his prescription for their child?

Prof Hugo: Oral steroids should be avoided, especially because eczema is a chronic disease, and oral steroids cannot be used chronically. Only in severe flare-ups a short course (5 to 7 days) is recommended. In some children (exceptionally) a longer treatment can be needed. However, this should be given in an EOD dose (= every other day). It is all a matter of trust in your doctor. If your child has severe eczema, needing oral steroids, I advise to see a paediatric allergist or paediatric dermatologist.

Alternative Eczema Treatments

Marcie Mom: Lots of parents are looking for a way to manage their child’s eczema (though a reminder that eczema is chronic, no miraculous cure) and may be willing to try ‘alternative treatments‘.

Many alternative treatments, including using natural remedies are marketed for eczema. Personally, I prefer sticking to moisturizing and appropriate use of steroid under doctor’s instruction. However, I understand the anxiety parents have when their child’s eczema hasn’t responded well to their doctor’s treatment.

What advice would you give a parent when deciding if they should try out a natural remedy? What is safe for them to try and what should they be wary of?

Prof Hugo: Only use treatment that has been scientifically proven to be safe and effective. Many alternative treatments are available, without any study and without prove of effect: don’t try them out!

Partially Hydrolysed Milk

Marcie Mom: I have experienced switching to partially hydrolysed milk when Marcie was diagnosed with eczema.

Some research showed that giving babies partially hydrolyzed milk may reduce chance of milk allergy. I understand that it doesn’t alter the allergic profile of a child but may reduce chances of allergy as part of the milk protein is broken down. What is an allergic profile (is it part of DNA)?

Prof Hugo: Hydrolysed milks can prevent cow’s milk allergy: that’s all. They have no effect on the long-term development of allergy. An allergic profile refers to the clinical presentation of allergy, and has nothing to do with DNA.

Food Restriction in Early Childhood

Marcie Mom: I also read that restricting a food in early childhood and introducing it later may lead to even more serious allergic reaction. What’s your understanding of how the same food allergy could progress from childhood to adulthood?

Professor Hugo: This is very individual and still confusing, because an intervention cannot be beneficial for all children, but should be tailored. More research on this is needed.

Vacuum Cleaner Selection

MarcieMom: Do you think the expensive vacuum cleaners are worth investing in? What should a parent look out for when buying a vacuum cleaner?

Prof Hugo: In case of house dust mite-allergy, a decent vacuum cleaner is recommended. However, most companies have no research data on their vacuum cleaner. Don’t spend too much money!

Sun & Haze Affect Kid’s Eczema?

MarcieMom: I read that the sun can dry the moisture on skin. Should children with eczema avoid the sun?

Prof Hugo: Active eczema (= skin inflammation) should avoid the sun.

Marcie Mom: I noticed that whenever there’s a haze (from neighbouring countries burning forests), my baby scratches a lot more. What could be in a haze and why does it irritate my baby’s skin?

Prof Hugo: Never been proven that the haze (= a type of pollution) has effect on eczema.

Living With Eczema: Mom Asks, Doc Answers!
Amazon.com
Living With Eczema: Mom Asks, Doc Answers!
$24.00
Buy
- 7%
Physiogel Calming Relief (AI) Cream 50ml, 1.7oz …
Amazon.com
Physiogel Calming Relief (AI) Cream 50ml, 1.7oz …
$24.99 $26.99 
Buy
CLn Facial Cleanser - Sensitive Skin Facial Cleanser, For Skin Prone to Dryness, Eczema, Rosacea, and Acne – Designed for the Delicate Skin of The Face, (2.5 Ounces)
Amazon.com
CLn Facial Cleanser - Sensitive Skin Facial Cleanser, For Skin Prone to Dryness, Eczema, Rosacea, and Acne – Designed...
out of stock
Buy
Categories
Doctor Q&A

Friday Feature – Eczema Q&A with Dr. B

Q&A Habitual Scratching and Eczema with Dr Christopher Bridgett

Dr. Christopher Bridgett is Hon. Clinical Senior Lecturer Imperial College at Chelsea & Westminster Hospital London. He is a psychiatrist with a special interest of using behavioural interventions to help people with atopic eczema, co-author of The Combined Approach at AtopicSkinDisease.com

Q&A with Dr Christopher Bridgett on Childhood Eczema and Habitual Scratching

This was originally a series of Friday Q&As in 2012 which had since been combined into one informative post.

Bedtime Routine for Eczema Kids

Marcie Mom: I set up a bedtime routine of reading books, singing songs, turning off all the lights and playing baby christian songs. We also pray for good night’s sleep! How does routine help a child’s behaviour and how can it help the child’s eczema?

Dr B: Your routine enables learning the desired consequence – a good nights sleep – if all the pieces of the sequence follow each other frequently enough, including the consequence of falling asleep. It’s best to move on from reading, and singing songs, to turning off the lights and saying prayers only when the signs of sleep arriving soon are quite clear!

When you think the child will sleep OK without the routine, it may be tempting to make some short cuts. I suggest that this would be a mistake! If on the other hand, a child is especially fraught, and therefore wakeful, it is best to go slowly along the routine, reading more stories, singing more songs, before the lights are turned off, and good night kisses are given.

Routine usually enables most of us to cope with everyday life. Generally following an established and happy routine means less stress, and changes in routine are usually stressful. And less stress means calmer skin, and less scratching… sounds good for eczema, I think!

Stress Control for Eczema Family

MarcieMom: Parents taking care of eczema children experience high stress levels, apparently as high as parents taking care of children with kidney illness. I’ve also read that stress can be passed onto babies, is there a chance that the stress that parents of newborn feel may worsen the eczema of the baby?

Without making parents even more stressed (that they are passing on the stress!), are there any tips for them to manage their own stress or to prevent stressing their child inadvertently?

Dr B: The causation of atopic eczema is multifactorial – there is no one factor, there are many, and they can be divided up into those that we have to accept, and those that we can do something about. First we need to draw up the list that applies in a particular case – stress is usually there on the list, and stress is usually a factor we can do something about!

Stress and frustration directly affects the skin – the skin is very sensitive to our emotions, and we all tend to scratch more when stressed and frustrated, and scratching soon becomes habitual – which is the cause of chronic eczema. There is no doubt that stress can be part of family life; kids become how they are through their parents, don’t they?

Marcie Mom: Most parents of eczema children have no time for themselves, let alone exercise. Obviously, we know exercise is good for us but how does exercise affect our psychological well-bring?

Dr B: Great question! We seem to live in stressful times. Under stress the body releases hormones like adrenaline, that facilitate fighting, or fleeing! In modern times we can’t do either usually, so it’s important to have a regular physical outlet. A healthy mind in a healthy body.

Marcie Mom: Also, parents of eczema child tend to have less couple time and higher stress in marriage. What simple and practical advice would you give them?

Dr B: The first step is the one you have already taken: recognize the problem. Coping always begins with confronting reality. Next how it leaves you feeling needs expression – don’t bottle it up, let it out, talk about it, understand it and think it through.

Then consider getting and accepting help – problems shared are problems halved. Experiment with new ways of doing things. Don’t take the situation for granted – there is usually a way of changing arrangements for the better. 

Steroid Side Effects

Marcie Mom: Some child’s skin turn brown where it frequently itches, being scratched and steroid creams have been applied. Some parents think it’s the steroid cream that causes the change in skin colour but I’ve read that the brown patch is caused by cells in skin (‘melanocytes’) releasing extra pigments from scratching. Which is true? Particularly it’s important to dispel any misperception of steroid when the risk of under-treatment due to steroid phobia is real.

Dr B: Both are true!

In the first case, yes steroid creams will change the colour of skin – they very slowly reduce the pigmentation, lightening the colour of the skin. The anti-inflammatory effect of the steroid reduces the activity of all skin cells, including the pigment cells – the “melanocytes”.

In the second case, cellular activity in skin is stimulated by habitual scratching, and this affects all cells, including the pigment cells – the “melanocytes”. So habitual scratching causes the skin to thicken up – lichenification – and colour up – hyperpigmentation. Both are characteristic of chronic atopic eczema.

Cradle Cap

MarcieMom: Some eczema babies also get cradle cap, and the cradle cap shampoo has to be used to massage the scalp and wash off the cradle cap. What’s the difference between cradle cap shampoo and normal baby shampoo?

Dr B: Aha! I think I can answer this… Yes, they are different. Cradle cap is seborrheic dermatitis of the new born and infants – it is usually harmless, and can clear on its own, without any special treatment. The regular baby shampoo will help reduce the rash, but specially formulated cradle cap shampoo is stronger – it may have salicylic acid in it for example. If the special shampoo is used, please make sure it is suitable for the age of the child!

Marcie Mom: I’ve also read that brushing a newborn hair helps to keep cradle cap away. Is that true? What does brushing hair do to the scalp?

Dr B: Yes, brushing the hair helps tidy things up, until the cradle capclears. With cradle cap there is excess sebum being produced. Sebum is the natural oil of the skin. Sebum is good for the skin and hair, in moderation – for example, it gives insulation against water loss. When birds preen they are spreading oil over their feathers, and that is what brushing the hair does – see how it shines! 

Swimming for Eczema Children

Marcie Mom: Some parents are very skeptical of bring their eczema child to swimming but my baby’s doctor recommended it. Just 10-15 minutes 3 times a week and wash off pool water and moisturize immediately. Will that also be your recommendation? Swimming is so fun and I hate to see eczema children being kept off it!

Dr B: Swimming is fun and good exercise – it also saves lives! So it’s good to say that swimming and atopic eczema usually go together just fine. The problem is caused by the water – it washes off a layer of the skin’s protection and leaves it very porous to water loss afterwards: a thin application of moisturizer before swimming protects against this. Make sure the application is thin though – no need to prepare for cross-channel swimming – see http://www.atopicskindisease.com/articles/TopTip1

Otherwise, the chemicals in the water of a swimming pool are disinfectants – chlorine, & bromine for example – they can be good for the skin, as their antibacterial effect is anti-inflammatory. However these additives can irritate too, so your procedure is a good one!

Moisturizing

MarcieMom: Moisturizing is important to maintain the skin barrier, particularly when eczema child has a weaker skin barrier that allows for more allergens to penetrate. The recommended guideline is about 500ml per week, that’s a lot and some children simply squirm when parents try to apply the moisturizer. What do you suggest parents can do to get their children to like being moisturized? Or even better, moisturize themselves!

Dr B: The use of a moisturizer – also called an emollient – is central to the care of atopic eczema.  The way it is used is very important – much more important than which one is used. Sometimes the better ones are the cheapest – and the best one is the one that is liked and used properly!

With children, as with adults, there are four key words to remember:

Thinly, Gently, Quickly and Often

and with the child it is very important to get it done quickly, and on afterwards to do something fun together, so that fun becomes the focus, not the moisturizing!

Getting the child to do their own moisturizing needs careful consideration: left to their own devices there is a good chance it will not get done properly – perhaps age and temperament come into it. 

Reactive Skin Reactive Mind?

Marcie Mom: It is mentioned in this article a comment by Sophie Worobec MD at University of Illinois that eczema children are “very bright” as the skin and the brain develop at the same time, so “very reactive skin and very reactive mind”. What do you think of this statement?

There seems to be an association between ADHD and eczema children. And have you seen more cases of ADHD for eczema patients?

Dr B: That there seems to be a close relationship between the skin and the mind is often referred to, and the development of the skin and the brain from the ectoderm of the early embryo is seen as relevant to this relationship – I sometimes say the brain can be called a specialized part of the skin!

But in reality the whole body is closely integrated. All the separate parts are interdependent through shared characteristics, and the overall function is enabled by circulating hormones and by the nervous system links between brain and body.

Both ADHD and atopic eczema are relatively common conditions. The recent reports of an association need to be treated with caution. I have no personal clinical experience of this reported association.

Tensed Baby

Marcie Mom: My baby has taken to tensing her stomach and legs in positions such as doing leg raisers or push-ups. My husband and I think it’s related to her being swaddled too much when young (we had to swaddle her due to scratching, sometimes looping a cloth around her limps cos the scratching was so bad). Do you think it is possible that she has learnt to use tensing to ease her itch and will this impact her psychologically? We certainly hope we haven’t made her gone bonkers!

Dr B: No, I do not think so! Probably what your baby is doing is “within normal limits” and is not due to swaddling, or to itching – and will have no psychological significance at all.

Marcie Mom: That’s comforting to know. Here’s another ‘crazy’ question from me. I frequently use finger food like biscuits (but only vitamin fortified, non-sugary, suitable for babies) to distract from my baby from scratching. My husband thinks I’m turning her into a glutton and soon she’ll have compulsive behaviour to keep eating. Is that true? 

Dr B: The importance of neutral/helpful alternative behaviours to scratching is fundamental to habit reversal – the new behaviour should not risk substituting a new problem for the old problem. I do not think what you describe is likely to lead to compulsive behaviour, but using eating as a habit reversal tactic does seem to encourage habitual snacking, and that may not be what you want to do?

Parental Guilt

Marcie Mom: Some parents have feedback that they feel guilty that they have either passed on the ‘bad gene’ or haven’t noticed their child scratching. What advice would you give to parents to cope with the guilt, which of course, isn’t justified!

Dr B: Both awareness of genetic inheritance, and coping with achild’s scratching are common human experiences and, as “facts of life”, need keeping in proportion. Some of us are more prone to self-blame than others. I think self-blame regarding genetic predisposition is quite unjustified. Failing to supervise a child’s scratching behaviour may be something to review. Sharing experiences in real time with others, and over the internet should be really helpful: great that you have this site!

Stop Scratching Eczema

Marcie Mom: Eczema babies seem to form a habit of scratching, mine even scratches my spouse or I when we’re beside her. How do you suggest parents can help to break the habit for your children (who can’t understand not to scratch nor appreciate the full negative effect of scratching)?

Dr B: Follow The Combined Approach to atopic eczema …. usehabit reversal behaviour modification to treat habitual scratching, together with optimal conventional treatment. To rescue a young child from chronic eczema please refer to Chapter 5 of our book“Atopic Skin Disease” – available to consult at www.atopicskindisease.com. 

Atopic Skin Disease: A Manual for Practitioners
Amazon.com
Atopic Skin Disease: A Manual for Practitioners
$56.95
Buy
- 9%
Baby Bath Silicone Brush by Fridababy | DermaFrida The SkinSoother Baby Essential for Dry Skin, Cradle Cap and Eczema (2 Pack)
Amazon.com
Baby Bath Silicone Brush by Fridababy | DermaFrida The SkinSoother Baby Essential for Dry Skin, Cradle Cap and Eczema...
$9.99 $10.99 
Buy
Mustela Foam Shampoo for Newborns, Baby Shampoo, Helps Prevent and Reduce Cradle Cap, with Natural Avocado Perseose, 5.07 Ounce
Amazon.com
Mustela Foam Shampoo for Newborns, Baby Shampoo, Helps Prevent and Reduce Cradle Cap, with Natural Avocado Perseose,...
$12.50
Buy
Last updated on 20 November, 2024 5:14 pm
Categories
Eczema Facts

Is steroid cream safe?

steroid potency ranking
Steroid Potency Ranking (from www.nsc.gov.sg)

Elomet cream

In my post on “Are you suffering from Steroid-Phobia?”, I have encouraged parents to be open to using steroids under the doctor’s supervision. My baby girl Marcie has taken a one-time 3 weeks oral steroid course and has been applying steroid cream prescribed by her specialist doctor, like the o.1% Elomet Cream.

A recent research study confirmed that there is no major negative effect on the skin of children who have applied topical steroid over approximately 10 months. I couldn’t find the original study, supposedly published in Pediatric Dermatology. You can however find a summary of the report, widely published by numerous online news websites here. Main points reported by the online news are:

– 70 children tested versus a control group of 22 children

– 10 months’ usage with experts checking on skin transparency, flattening, shiny ‘glazed’ appearance or dilated blood vessels

– Result is no evidence of skin thinning, stretch marks or scars

– Do note that there is also comment that the sample size is too small, with information such as their age, doses not provided

For parents fearing the use of too potent steroid, below is a potency ranking chart from National Skin Centre’s website.

Molnlycke 5923 Tubifast Garments Glove, Child Small
Amazon.com
Molnlycke 5923 Tubifast Garments Glove, Child Small
$20.46
Buy
Epaderm Emollient For Dry Skin - 500G
Amazon.com
Epaderm Emollient For Dry Skin - 500G
$19.94
Buy
- 6%
Tubifast 1.4 Tubular Bandage #2434 (Red Line)""
Amazon.com
Tubifast 1.4 Tubular Bandage #2434 (Red Line)""
$11.00 $11.74 
Buy
Last updated on 20 November, 2024 4:54 pm
Categories
Eczema Facts

Are you suffering from Steroid-Phobia?

Baby Sleeping scratching head
Baby Sleeping - Was she scratching her head?

Eczema on baby’s face

You may be fearful of using steroids, as many parents (myself included) are. The fear could partly arise due to the negative news on steroid abuse by athletes and partly due to its side effects. If you have googled steroids, you will find numerous websites ‘promising’ treating eczema without using steroids. When Marcie’s doctor put her on oral steroid, I had a lot of reservations and fear and remembered scaring myself to death googling all the side effects.

But after going through resisting steroid use to using mild steroid lotion & cream and a 3-week oral steroid course for Marcie, I like to encourage you not to fear using steroids but instead use it under the instruction of your doctor, preferably a specialist.

How much steroid is ok?

Where there is no inflammation, just dry skin that’s itchy – I’d recommend using lots of moisturizer. Keeping the skin cool helps to relief the itch, so try turning the air-conditioner colder. (I sometimes give Marcie a cold drink bottle to hold and its works!)

Where there is inflammation and the skin is reddish and itchy – I’d clean the skin with cool liquid chlorhexidine (antiseptic) and apply mild steroid lotion or cream. For areas with delicate skin such as the face, I’d apply a 0.5% hydrocortisone and for other areas like the knees or elbows or hands, I’d apply a 1% elomet cream. Marcie’s doctor’s instructions were not to apply more than twice a day. So far, I have only needed to apply 2 to 3 days in a row, not exceeding twice a day, and the skin will go back to normal.

You can refer to this chart extracted from patient.co.uk for how much to apply, measured using fingertip units (ftu):

For a 3-6 month old child

  • Entire face and neck – 1 FTU
  • An entire arm and hand – 1 FTU
  • An entire leg and foot – 1.5 FTUs
  • The entire front of chest and abdomen – 1 FTU
  • The entire back including buttocks – 1.5 FTUs

For a 1-2 year old child

  • Entire face and neck – 1.5 FTUs
  • An entire arm and hand – 1.5 FTUs
  • An entire leg and foot – 2 FTUs
  • The entire front of chest and abdomen – 2 FTUs
  • The entire back including buttocks – 3 FTUs

What happened to Marcie after taking oral steroid?

You may be wondering why I’m encouraging parents to be open to using steroids when I initially did not even apply steroid on Marcie. It was very difficult to get the eczema under control and her eczema will suddenly just flare and affect her whole body. However, a one-time 3 weeks reducing dosage of oral steroid, prednisolone, really helped to keep the eczema manageable.  Marcie’s rashes disappeared within the first 2 days of the oral steroid, but gradually came back as the dosage is reduced. I worried a lot after reading the side effects of steroids such as thinning of skin, acne and damage of blood vessels. I am very glad that I chose to trust Marcie’s doctor and persisted with the 3 weeks course despite being fearful everyday. After the 3 weeks course, Marcie’s doctor said he will not give Marcie any treatment that is not 100% safe and will not give her another oral steroid course because that will not be safe. I read later that stopping an oral steroid course halfway causes more harm than following through and makes it more difficult for the doctor to decide on the next step.

After the oral steroid course, there are still rashes on and off, triggered by hot weather, sweat but never affecting her whole body with no reason. This makes it a lot easier to manage and Marcie has been a much happier baby since.

Octenisan Wash Lotion, 500ml by Schulke and Mayer
Amazon.com
Octenisan Wash Lotion, 500ml by Schulke and Mayer
out of stock
Buy
- 11%
Hibiclens Antimicrobial/Antiseptic Skin Cleanser, 32 Fluid Ounce Bottle, for Antimicrobial Skin Cleansing
Amazon.com
Hibiclens Antimicrobial/Antiseptic Skin Cleanser, 32 Fluid Ounce Bottle, for Antimicrobial Skin Cleansing
$20.32 $22.99 
Buy
CeraVe Itch Relief Moisturizing Cream Tub 12 oz with Pramoxine Hydrochloride and Ceramides for Relief From Itch and Irritation
Amazon.com
CeraVe Itch Relief Moisturizing Cream Tub 12 oz with Pramoxine Hydrochloride and Ceramides for Relief From Itch and...
$19.99
Buy
Last updated on 20 November, 2024 9:47 pm